Psilocybin and DMT: family or strangers? What truffles and the spirit molecule share

One you buy legally as a fresh product, the other is a prohibited substance that we do not sell. And yet psilocybin, the active compound in magic truffles, and DMT are close chemical relatives. How does that work, and why does the experience feel so different?

What is a tryptamine?

Tryptamines are a group of compounds with a shared chemical core. That core closely resembles serotonin, a substance your body uses itself to regulate mood, among other things. Both psilocin, which is what truffles are converted into in your body, and DMT are tryptamines. That is why they work in related ways in the brain.

Why truffles and DMT are family

Both compounds act on the same group of serotonin receptors in the brain, and that is why they can both change perception, mood and thoughts so profoundly. On the family tree of psychedelics they sit close together, with serotonin as a shared ancestor. Chemically, they are cousins.

Why the experience still differs so much

The big difference lies not so much in the family, but in how and how long the substance works. Psilocybin is taken orally and works for hours, in a gradual arc, see how long do magic truffles last. DMT is smoked, hits within a minute and is over after a few minutes. Same family, very different journey.

What this means for you

Of the two, only psilocybin, in the form of magic truffles, is legally available in the Netherlands, and it is also easier to keep track of thanks to its calm progression. We do not sell DMT. If you want to start with the legal relative, read our beginner's guide to magic truffles. The basics on DMT are in what is DMT.

This article is educational and informational, not medical advice. Only use magic truffles if you are 18 years or older and be mindful of the contra-indications.